{"created":"2023-06-19T08:45:50.098201+00:00","id":1225,"links":{},"metadata":{"_buckets":{"deposit":"bf79cfda-61a6-47b0-b507-9249f8d9b866"},"_deposit":{"created_by":25,"id":"1225","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"1225"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:00001225","sets":["4:71:328:329"]},"author_link":["2641"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1・2","bibliographicPageEnd":"51","bibliographicPageStart":"47","bibliographicVolumeNumber":"68","bibliographic_titles":[{}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"：同種造血幹細胞移植後に発症する移植片対宿主病（GVHD）は，しばしば診断や治療に苦慮する移植関連の主要な合併症である．移植後早期にみられる急性GVHDはドナー由来のT細胞が宿主を異物とみなすことによって生じるが，その他にも様々な免疫反応がGVHDの病態を形成する．移植後のマクロファージの活性化も急性GVHDの病態形成に重要であることが示唆されるものの，そのメカニズムや臨床的意義は十分に解明されていない．そこで本総説では，まず急性GVHDの診断，病態，そして診断・予後因子として有用な新規バイオマーカーに関するこれまでの知見を概説する．さらに，急性GVHDの病態とマクロファージの活性化との関連に着目し，現在我々が行っている臨床研究を紹介しつつ，移植後のマクロファージの活性化が急性GVHDをはじめとした移植関連合併症に与える影響について考察する．","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"横浜市立大学医学会"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0372-7726","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宮崎　, 拓也"},{"creatorName":"ミヤザキ, タクヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-08-08"}],"displaytype":"detail","filename":"08_Miyazaki.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"横浜医学68巻1・2号","url":"https://ycu.repo.nii.ac.jp/record/1225/files/08_Miyazaki.pdf"},"version_id":"db366cad-b155-441d-80b6-bb2cd7fb0d47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"急性移植片対宿主病｜造血幹細胞移植｜マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"acute graft-versus-host disease｜hematopoietic stem cell transplantation｜macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"同種造血幹細胞移植後の急性GVHDの病態とマクロファージの活性化との関連","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"同種造血幹細胞移植後の急性GVHDの病態とマクロファージの活性化との関連"},{"subitem_title":"ASSOCIATION BETWEEN ACUTE GVHD AND MACROPHAGE ACTIVATION IN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"25","path":["329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-08-08"},"publish_date":"2017-08-08","publish_status":"0","recid":"1225","relation_version_is_last":true,"title":["同種造血幹細胞移植後の急性GVHDの病態とマクロファージの活性化との関連"],"weko_creator_id":"25","weko_shared_id":25},"updated":"2023-06-19T09:41:14.761659+00:00"}