{"created":"2023-06-19T08:46:18.125074+00:00","id":1799,"links":{},"metadata":{"_buckets":{"deposit":"80f75cf1-61b4-48c7-b64c-87c9933e5f88"},"_deposit":{"created_by":25,"id":"1799","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"1799"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:00001799","sets":["4:71:396:397"]},"author_link":["3351"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-01-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"74","bibliographicPageStart":"67","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"横浜医学"},{"bibliographic_title":"Yokohama Medical Journal","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"個々の分子活性の単純なON・OFFだけでなく，その時空間的な変動パターンにも細胞機能の制御メカニズムが内包すると示唆される．ところがこうした分子活性の時空間ダイナミクスがもつ生理的意義や個体レベルへの寄与の程度は，未だ多くが謎に包まれている．分子の時空間ダイナミクスにアプローチする手法として，生きた細胞の中で分子活性を光で可視化・操作する手法がある．光を用いることで，神経スパインなどのわずか数マイクロメートルの微小空間においても分子活性を迅速に操作することができ，その表現系を可視化することで，分子機能の時空間ダイナミクスについて， 因果的な解析が可能になる．そこで本項では，近年注目される光で分子機能を不活性化するCALI法に関する最先端技術について解説する．\n","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"横浜市立大学医学会"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0372-7726","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹本, 研"},{"creatorName":"タケモト, キワム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-07-02"}],"displaytype":"detail","filename":"10_Takemoto.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"横浜医学70巻1号（竹本研）","url":"https://ycu.repo.nii.ac.jp/record/1799/files/10_Takemoto.pdf"},"version_id":"9c486508-6579-4250-8077-d8d2a4b38b4e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CALI法｜光操作｜AMPA受容体｜学習記憶","subitem_subject_scheme":"Other"},{"subitem_subject":"CALI｜optical manipulation｜AMPA receptor｜learning and memory","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"蛋白質機能の光操作とその応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"蛋白質機能の光操作とその応用"},{"subitem_title":"optical technology for inactivation of protein function","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"25","path":["397"],"pubdate":{"attribute_name":"公開日","attribute_value":"2019-07-02"},"publish_date":"2019-07-02","publish_status":"0","recid":"1799","relation_version_is_last":true,"title":["蛋白質機能の光操作とその応用"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-06-19T09:33:11.108143+00:00"}