{"created":"2025-01-09T01:09:10.168350+00:00","id":2003372,"links":{},"metadata":{"_buckets":{"deposit":"f1d38521-fb96-4dcb-815f-0a2cab2f6fca"},"_deposit":{"created_by":25,"id":"2003372","owner":"25","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"2003372"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:02003372","sets":["4:71","4:71:1709270345492","4:71:1709270345492:1736232811823"]},"author_link":[],"item_10002_biblio_info_7":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-12-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicNumberOfPages":"7","bibliographicPageEnd":"591","bibliographicPageStart":"585","bibliographicVolumeNumber":"75","bibliographic_titles":[{"bibliographic_title":"横浜医学","bibliographic_titleLang":"ja"},{"bibliographic_title":"YOKOHAMA MEDICAL JOURNAL","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"膵癌は5年生存率8.5％と予後不良であり，根治的な外科治療が可能な早期診断がカギとなる．我々は地域連携システムと精密画像診断法を用い膵癌の早期診断を推進し，切除率を向上させ大きさ10mm以下の小膵癌を早期診断することで，膵癌の予後改善を目指す横浜早期膵癌診断プロジェクトを開始した．膵癌のリスクを有する症例を，地域連携システムを利用して，当院に紹介してもらい，Dual Energy CT（DECT），超音波内視鏡（EUS）を使用して精密画像精査を行っている．また我々は液体クロマトグラフィー質量分析法（LC/MS/MS）等を用いて，困難とされてきたグライコプロテオミクスによりバイオマーカーを効率的に探索する方法を開発した．既に膵癌のほか，乳癌，大腸癌などの新たな血液糖タンパク質バイオマーカーを発見し，企業との共同研究につなげているが，早期膵がん診断マーカー開発には至っていなかった．そこで今回，早期膵癌プロジェクトにより集積した症例を対象に膵癌の早期診断における血液バイオマーカーの有用性の検討を実臨床下で行うことを開始した．腫瘍部と非腫瘍部の比較グライコプロテオミクスによりバイオマーカー候補を絞り込み，エクソソームや血液中のマーカー候補を定量解析することで，バイオマーカーの特定を試みている．本プロジェクトの目的は，膵癌のDECT・EUSによる画像診断による早期診断と，有用な血液バイオマーカーを同定することであり，患者の生命予後の延長に寄与することである．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_10002_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"names":[{"name":"Yusuke Kurita","nameLang":"en"}]}]},"item_10002_identifier_registration":{"attribute_name":"identifier_registration","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15015/0002003372","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"横浜市立大学医学会","subitem_publisher_language":"ja"}]},"item_10002_source_id_9":{"attribute_name":"item_10002_source_id_9","attribute_value_mlt":[{"subitem_source_identifier":"0372-7726","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"栗田　裕介","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-09"}],"displaytype":"detail","fileDate":[{"fileDateType":"Updated","fileDateValue":"2025-01-09"}],"filename":"09 Kurita.pdf","filesize":[{"value":"1 MB"}],"format":"application/pdf","licensetype":"license_5","url":{"label":"総説　栗田　裕介","objectType":"fulltext","url":"https://ycu.repo.nii.ac.jp/record/2003372/files/09 Kurita.pdf"},"version_id":"f2de7300-1218-4a89-a0c7-b903c17a2f4a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"膵癌｜超音波内視鏡｜Dual Energy CT｜バイオマーカー｜腫瘍マーカー","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic cancer｜Endoscopic ultrasound｜Dual Energy CT｜tumor marker｜腫瘍マーカー","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DECT/EUSによる画像診断とバイオマーカーの融合による膵癌早期診断法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DECT/EUSによる画像診断とバイオマーカーの融合による膵癌早期診断法の確立","subitem_title_language":"ja"},{"subitem_title":"ESTABLISHMENT OF EARLY DIAGNOSIS OF PANCREATIC CANCER BY FUSION OF DECT/EUS IMAGING AND BIOMARKERS","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"25","path":["71","1709270345492","1736232811823"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-09"},"publish_date":"2025-01-09","publish_status":"0","recid":"2003372","relation_version_is_last":true,"title":["DECT/EUSによる画像診断とバイオマーカーの融合による膵癌早期診断法の確立"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2025-01-10T04:01:59.911745+00:00"}