{"created":"2023-06-19T08:46:33.619628+00:00","id":2113,"links":{},"metadata":{"_buckets":{"deposit":"ab7ca1b7-050b-432d-b10a-b0ca66f20ac2"},"_deposit":{"created_by":25,"id":"2113","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"2113"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:00002113","sets":["4:71:433:436"]},"author_link":["3855"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"601","bibliographicPageStart":"597","bibliographicVolumeNumber":"71","bibliographic_titles":[{"bibliographic_title":"横浜医学"},{"bibliographic_title":"Yokohama Medical Journal","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"新規生理活性物質の同定は医学・生物学研究における重要課題の一つである．L-3,4-dihydroxyphenylalanine（L-DOPA，レボドパ，ドーパ）の薬理作用はドパミンへの変換を介してのみ発現し，それ自体は不活性のアミノ酸であると考えられてきた．一方，ドーパがある一定の刺激により遊離されること，ドパミンへの変換を介さない生体応答が存在し，その応答がドーパ類縁化合物により拮抗されること等，ドーパが神経伝達物質として機能するという知見が集積されてきた．その受容体の存在は長らく不明であったが，筆者らは，ドーパ受容体としてGタンパク質連関型受容体の一つであるGPR143を同定し，その機能解析を進めている．本稿において，ドーパ神経伝達物質仮説の研究背景を踏まえ，これまで明らかにしてきたドーパの新たな生理機能について概説する．","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"横浜市立大学医学会"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0372-7726","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増川, 太輝"},{"creatorName":"マスカワ, ダイキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3855","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-01-18"}],"displaytype":"detail","filename":"07_Masukawa.pdf","filesize":[{"value":"949.1 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"横浜医学71巻4号（増川太輝）","url":"https://ycu.repo.nii.ac.jp/record/2113/files/07_Masukawa.pdf"},"version_id":"971b679c-5581-4c2b-bb29-d8a932083861"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"L-DOPA｜神経伝達物質｜GPR143","subitem_subject_scheme":"Other"},{"subitem_subject":"L-DOPA｜Neurotransmitter｜GPR143","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"L-DOPA性神経伝達の生理学的意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"L-DOPA性神経伝達の生理学的意義"},{"subitem_title":"PHYSIOLOGICAL ROLES OF L-DOPAERGIC NEUROTRANSMISSION","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"25","path":["436"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-18"},"publish_date":"2021-01-18","publish_status":"0","recid":"2113","relation_version_is_last":true,"title":["L-DOPA性神経伝達の生理学的意義"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-06-19T09:23:49.693215+00:00"}