{"created":"2023-06-19T08:46:41.178790+00:00","id":2263,"links":{},"metadata":{"_buckets":{"deposit":"174b05e2-56ca-4106-8d1e-5a1c123a489c"},"_deposit":{"created_by":25,"id":"2263","owners":[25],"pid":{"revision_id":0,"type":"depid","value":"2263"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:00002263","sets":["4","4:71:453:454"]},"author_link":["4149","4160","4157","4143","4148","4155","4163","4144","4159","4162","4150","4142","4152","4158","4146","4151","4145","4153","4161","4154","4147","4156"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"14","bibliographicPageStart":"9","bibliographicVolumeNumber":"72","bibliographic_titles":[{"bibliographic_title":"横浜医学"},{"bibliographic_title":"YOKOHAMA MEDICAL JOURNAL","bibliographic_titleLang":"en"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"症例は57歳男性．検診異常に対し施行した上部消化管内視鏡で胃癌が疑われ，当科紹介となった．精査の結果，上部消化管内視鏡で胃体中下部小弯に 2 型病変を認め，また腹部造影CTで胃病変と一塊となった多数のリンパ節腫大と腹部造影MRIで多発肝転移（S6，S7）を認めた．LM，Less，Type2，46㎜，pap-tub1-tub2，HER2 score3，cT4aN2（bulky N）H1（M1 HEP）P0CY0，cStageⅣの切除不能進行胃癌と診断し，XP＋trastuzumab （capecitabine 1500㎎/㎡ 1 日 2 回14日間，CDDP 80㎎/㎡/日day 1 投与，trastuzumab 8 ㎎/㎏day 1 投与： 3 週 1 コース）併用化学療法を施行した．腎障害のため 3 コース目からCDDPは中止としたが， 1 コース施行後にPR， 6 コース施行後にPET-CTで原発巣，リンパ節転移，肝転移はいずれも集積を認めずCRと判定し，ycT3（SS）N0M0，ycStageⅡAと診断した．Conversion Surgeryの適応として，開腹幽門側胃切除，D 2 郭清，oux-en-Y再建術を施行した．\n術後病理診断では化学療法の組織学的効果判定はGrade 3であった．術後補助化学療法としてX＋trastuzumaを 4 コース施行したが，術後 2 年 3 か月無再発生存中である．Conversion Surgeryの適切なタイミング，適格基準については一定の見解は得られていないが，今後の症例の蓄積，検討や前向き研究によりさらなる予後改善が期待される．","subitem_description_type":"Abstract"}]},"item_10002_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15015/00002114","subitem_identifier_reg_type":"JaLC"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"横浜市立大学医学会"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0372-7726","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河原, 慎之輔"},{"creatorName":"カワハラ, シンノスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"青山, 徹"},{"creatorName":"アオヤマ, トオル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村岡, 枝里香"},{"creatorName":"ムラオカ, 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stage Ⅳ gastric cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conversion surgery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trastuzumab","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"XP＋Trastuzumab療法で完全寛解後にConversion Surgeryを 施行し得たHER2陽性StageⅣ切除不能進行胃癌の 1 例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"XP＋Trastuzumab療法で完全寛解後にConversion Surgeryを 施行し得たHER2陽性StageⅣ切除不能進行胃癌の 1 例"},{"subitem_title":"A CASE OF HER-2-POSITIVE, STAGE IV, UNRESECTABLE, ADVANCED GASTRIC CANCER TREATED BY CAPECITABINE, CISPLATIN, AND TRASTUZUMAB CHEMOTHERAPY  WITH COMPLETE RESPONSE FOLLOWED BY CONVERSION SURGERY","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"25","path":["4","454"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-04-26"},"publish_date":"2021-04-26","publish_status":"0","recid":"2263","relation_version_is_last":true,"title":["XP＋Trastuzumab療法で完全寛解後にConversion Surgeryを 施行し得たHER2陽性StageⅣ切除不能進行胃癌の 1 例"],"weko_creator_id":"25","weko_shared_id":-1},"updated":"2023-06-19T09:17:46.447375+00:00"}