{"created":"2023-06-19T08:45:33.292261+00:00","id":892,"links":{},"metadata":{"_buckets":{"deposit":"9bf73b98-544f-43eb-9609-ce93bbc85c68"},"_deposit":{"created_by":3,"id":"892","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"892"},"status":"published"},"_oai":{"id":"oai:ycu.repo.nii.ac.jp:00000892","sets":["4:71:315:316"]},"author_link":["2148","2147","2150","2151","2149","2146"],"item_2_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-01-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"55","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"横濱醫學"},{"bibliographic_title":"The Yokohama medical journal","bibliographic_titleLang":"en"}]}]},"item_2_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"1970年代以降,静岡,山梨両県の富士川流域にCreutzfeldt-Jakob病(CJD)が多いことは知られていたが,筆者らは同地域に位置する共立蒲原総合病院で1999年の1年間に3例のCJD患者を経験したことから,静岡,山梨両県の36施設に対し,1990年から1999年の10年間にわたるCJD患者についてのアンケート調査を行なった.36施設中26施設から文献例を含む合計34例のCJD患者が確認された.症例は男性16例,女性18例で,平均発症年齢は62.5±10.7歳であった.遺伝子変異が10/34例(29.4%)にみられ,全例がcodon 200の変異(CJD^<200>)であり,そのうち2家系に家族内発症を認めた.臨床所見では高率にミオクローヌス(95.7%)と脳波上の周期性同期性放電(periodic synchronous discharge,PSD)(95.7%)を認め,従来の孤発例やCJD^<200>の特徴と一致していた.過去10年間では富士川中流地区に,1999年の1年間では下流地区に,それぞれCJD患者の有為な集積が確認された(ボアソン分析でp<0.01).さらにCJD^<200>の10例のうち8例が富士川流域(7例が中流～下流地区)の出身であったことから,同地区がCJD^<200>の主たる集積地区と考えられた.また周辺の静岡市から三島市にかけても症例(CJD^<200>2例を含む)が散見され,同地区まで含めた範囲をCJD関連地域として注目すべきと考えた.","subitem_description_type":"Other"}]},"item_2_description_11":{"attribute_name":"抄録(英)","attribute_value_mlt":[{"subitem_description":"An epidemiological study of Creutzfeldt-Jakob disease (CJD) was carried out during the period between 1990 and 1999. A total of 34 cases with CJD was collected from the information provided by neurologists, psychiatrists, and neurosurgeons in Shizuoka and Yamanashi Prefecture. There was no significant difference between males and females. The average age of onset was 62.5 years, with high occurrence seen in patients in their fifties, sixties, and seventies. The mean duration of CJD was 7.3 months. There were no cases with a cadaveric dural graft. There were two families with CJD patients having codon 200 mutations. Myoclonus occurred in 95.7% of cases and there were electroencephalographic (EEG) tracings with periodic synchronous discharges (PSD) in 95.7% of the cases. Ten patients had a mutation at codon 200 of prion protein gene (CJD^<200>) . In the middle reaches of the Fuji River basin (Yamanashi Prefecture), the retrospective incidence of CJD between 1990 and 1999 was 5.77 cases/million/annum; highly significant clustering (p = 0.01) was confirmed in this area. The point prevalence rate in 1999 at the lower reaches of the Fuji River (eastern part of Shizuoka Prefecture) was 9.78 cases/million/annum. These results demonstrated significant clusters of CJD patients at the middle and lower reaches of the Fuji River. The incidence of CJD^<200> appeared to be much higher in these areas than other areas in Japan.","subitem_description_type":"Other"}]},"item_2_description_15":{"attribute_name":"表示順","attribute_value_mlt":[{"subitem_description":"11","subitem_description_type":"Other"}]},"item_2_description_16":{"attribute_name":"アクセション番号","attribute_value_mlt":[{"subitem_description":"KJ00004192659","subitem_description_type":"Other"}]},"item_2_description_8":{"attribute_name":"記事種別(日)","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_type":"Other"}]},"item_2_description_9":{"attribute_name":"記事種別(英)","attribute_value_mlt":[{"subitem_description":"ORIGINAL ARTICLE","subitem_description_type":"Other"}]},"item_2_source_id_1":{"attribute_name":"雑誌書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00246369","subitem_source_identifier_type":"NCID"}]},"item_2_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03727726","subitem_source_identifier_type":"ISSN"}]},"item_2_text_6":{"attribute_name":"著者所属(日)","attribute_value_mlt":[{"subitem_text_value":"横浜市立大学大学院医学研究科神経内科"},{"subitem_text_value":"/ /"}]},"item_2_text_7":{"attribute_name":"著者所属(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Yokohama City University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Yokohama City University School of Medicine"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Hadano Red Cross Hospital"},{"subitem_text_language":"en","subitem_text_value":"Department of Neurology, Yokohama City University School of Medicine"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"戸田, 宏幸"},{"creatorName":"トダ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2146","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"/, /"},{"creatorName":"ハキイ, ヤスヒト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"2147","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TODA, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2148","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HAKII, Yasuhito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2149","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TANIGAWA, Akiyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2150","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"KUROIWA, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"2151","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-04-21"}],"displaytype":"detail","filename":"KJ00004192659.pdf","filesize":[{"value":"955.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00004192659.pdf","url":"https://ycu.repo.nii.ac.jp/record/892/files/KJ00004192659.pdf"},"version_id":"2581c597-ac50-40f0-be19-ea7205e2ed00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Creutzfeldt-Jakob病","subitem_subject_scheme":"Other"},{"subitem_subject":"富士川流域","subitem_subject_scheme":"Other"},{"subitem_subject":"codon 200変異","subitem_subject_scheme":"Other"},{"subitem_subject":"地域集積性","subitem_subject_scheme":"Other"},{"subitem_subject":"Creutzfeldt-Jakob disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"basin of Fuji River","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"codon 200 mutation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cluster area","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"富士川流域におけるCreutzfeldt-Jakob病の疫学的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"富士川流域におけるCreutzfeldt-Jakob病の疫学的検討"},{"subitem_title":"A RETROSPECTIVE STUDY OF CREUTZFELDT-JAKOB DISEASE (CJD) IN THE BASIN OF THE FUJI RIVER DURING THE TEN-YEARS FROM 1990 to 1999","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["316"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-04-21"},"publish_date":"2017-04-21","publish_status":"0","recid":"892","relation_version_is_last":true,"title":["富士川流域におけるCreutzfeldt-Jakob病の疫学的検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-19T09:59:16.829938+00:00"}